This is especially problematic in intervention studies [ 29] where the goal of treatment is to foster rehabilitation and reentry into normative roles and relationships.
Most fused images are tolerable for image interpretation without problematic manual intervention, and they often have significant clinical impact.
For those who did not identify substance use as problematic, the intervention was sufficiently flexible to allow therapists to work with other patient led problems.
The choice of outcome measures is especially problematic in evaluating complex interventions, interventions for people with long-term health problems, and interventions that aim to bring about a wide range of treatment effects and behaviour change.
This bias towards promotion of drugs rather than lifestyle change is problematic because lifestyle interventions should be first line treatment for many hypertensive patients, and the foundation of ongoing treatment even when medications are used.
Importantly, after education, participants were significantly less likely to believe that offering community-based HCV screening without guarantee of universal treatment would be problematic (49% pre-intervention believed this would be problematic vs. 35% post-education, p = 0.02).
This is problematic when educational interventions to foster nurses' competence are designed.
The use of such measures to model disease progression in NPIs may be problematic, as such interventions often not only focus on slowing progression of the disease, but also on independence of patients and quality of life (both patients' and caregivers') such as those assessed in Martikainen [29].
The lack of studies performed in a relevant location is particularly problematic for nonpharmacologic interventions targeting behavioural changes (e.g., education, counselling), because the results of such trials could be strongly influenced by cultural conditions [20], [30].
This, in turn, makes replication of successful interventions problematic.
