Despite their already long service lives, this impact may in time become problematic for historic buildings, which, by nature of their design and construction, interact with moisture and climate to a far greater degree than modern buildings.
A frequency oriented approach is preferred because a problematic separation in time is circumvented when incident waves overlap their reflections from the nearby notch.
Extrapolating highly variable estimates produced using problematic methods in time and space creates extreme uncertainty and low confidence in these scaled estimates.
Traditional ways of identifying differentially expressed genes, such as the t-test, are problematic in studying time-series data since there is a need to carry out hypothesis tests on individual time points.
There may be some concern that the use of prevalent cases is problematic in any time-to-event analysis even though this was taken into account in the analysis.
On the contrary, the recombinant fusion of many different chimeras could be problematic in terms of time, different levels of expression, or even impossibility to synthesize the protein.
Furthermore, robust assessment of time from onset of symptoms to hospital admission might be problematic in that these times rely on patients' reports and thus cannot be independently verified, whereas door-to-balloon times are probably more accurately recorded.
More problematic was the closeness in time to the Newtown massacre, which served to cast suspicion and guilt in tendentious ways.
Even a year after the American invasion, he said, "obtaining clear, truthful information from the senior Iraqi leadership has been problematic even at this point in time".
Does the school involve the parents in dealing with problematic behavior, and do they believe in time out or even suspending the child?
