Sentence examples for problematic in the study of from inspiring English sources

The precision for geographic risk estimates has been especially problematic in the study of childhood cancer.

Inferring that differential outcomes are due to treatment differences requires one, among other things, to assume no period/time effect, which is especially problematic in the study of episodic disease states such as schizophrenia.

Comparisons between reconstructed states at internodes [ 33] were not included, as these are problematic in the comparative study of substitution rates [see Additional file 2].

They noted that these items had also proved problematic in studies of the original version (Gomez & Fisher, 2005a, 2005b) and concluded that future research with the Portuguese version should either exclude or revise these items in order to improve the psychometric properties of the instrument.

These cognitive data derived from the CDR testing showed that NS2359 improved attention, episodic memory, and working memory in these adults with ADHD – areas previously identified as problematic in separate studies of adults with ADHD [ 31].

Adherence to therapeutic protocols is problematic in many studies of TJA rehabilitation and warrants subgroup analysis to determine whether higher adherence (e.g., greater treatment dosage) results in larger treatment effects.

This potential confounding may be particularly problematic in observational studies of older adults with complex chronic diseases given that ADL impairment may be a stronger predictor of some outcomes such as LTC placement or mortality than some commonly used measures of medical comorbidity [ 17- 19].

The study of the transcriptome in groups with different ACOO is particularly problematic in that most of these studies are performed on Epstein Barr virus (EBV) immortalized cell lines.

For these reasons the study of adjuvant therapies in RRP is problematic.

This can make experiments such as the study of molecular motor stepping[8], [9] or forced unfolding[10] problematic in such devices.

The loss of power may become problematic in the context of genomewide association studies (GWAS) where it is critical to achieve a genomewide significance level in order to judge a positive finding.