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The precision for geographic risk estimates has been especially problematic in the study of childhood cancer.
Inferring that differential outcomes are due to treatment differences requires one, among other things, to assume no period/time effect, which is especially problematic in the study of episodic disease states such as schizophrenia.
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We expected this issue to be especially problematic in this study since the individuals (both cases and controls) were recruited in more than a hundred centers across the world and later grouped together based on their self-reported ethnicity.
This was not problematic in the present study because all antidepressants require a written prescription.
Recruitment was problematic in the feasibility study as there is no specific electronic diagnostic code for chronic pain.
Comparisons between reconstructed states at internodes [ 33] were not included, as these are problematic in the comparative study of substitution rates [see Additional file 2].
This strategy is problematic in the present study because individual LODs depend on the amount of adipose tissue in that particular sample, such that LOD varied by up to two orders of magnitude between samples below LOD for the same organochlorine.
The 80% response rate among those who were sent questionnaires suggests these factors were not problematic in this study.
What was always problematic in these studies was that the CNTs were fibrous particles of similar size to asbestos particles.
Our findings indicate that the HPV and Flu vaccines were distinguished from the other vaccines as being particularly problematic by parents in the study.
The high prevalence of problematic drinking identified in the study, and the varied patterns of heavy drinking behaviours, together with links between drinking and crime and recidivism, support the argument for more extensive provision of alcohol-focused interventions in prison and related criminal justice settings.
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CEO of Professional Science Editing for Scientists @ prosciediting.com