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Experimental studies are also problematic in the setting of human labor for ethical reasons.
Systematic bias, such as white coat hypertension [ 46], is generally less problematic in the setting of a randomised controlled trial.
Thus, increasing exposure to ambient air pollution in Westernized countries may be particularly problematic in the setting of the obesity epidemic.
Having pregnant women take on a communicative role in situations where they might not fully be able to do so is not only problematic in the setting of Dutch midwifery and obstetrics, but in the entire health care sector.
This is particularly problematic in the setting of systemic factors, such as functional disability, performance-based outcomes requiring the use of multiple joint sites, serum/urine biomarkers, and genetics, which are necessarily a reflection of the whole-body burden of OA and the impact of that burden on the individual.
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Fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) have been of recent interest, particularly for use in populations in which interpretation of glycated hemoglobin (A1C) may be problematic (1– 3), such as in the setting of anemia, hemolysis, or renal disease (4– 6).
Much of the work on the problematic aspects of social support interactions has been in the setting of chronic conditions such as arthritis, HIV, and cancer.
Unrecognized, as well as underappreciated, glenoid bone loss in the setting of glenohumeral instability is especially problematic.
In the setting of an observational cohort study this is a problematic assumption when using exposure at study baseline.
This suggests that even in the setting of diabetes and CKD, universal recommendations regarding salt intake may be problematic.
In contrast to the experimental setting, defining worsening hypoxaemia related to transfusion is problematic in the clinical setting.
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