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Particularly, in cases where real-time observation over a long time period (>10 min) with single molecule sensitivity is necessary to detect enzymatic reactions with slow kinetics, photobleaching and blinking of fluorophores can be problematic in the interpretation of single molecule data.
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Given that subject motion can be especially problematic for the interpretation of group differences in DWI data77, datasets with mean slice-by-slice root mean square displacement >0.7 mm were excluded from all further analyses.
Therefore, the direct determination of the SOM for the creation of training sets in machine learning approaches is problematic, and the interpretation of the predicted results is ambiguous.
However, transforming this into larger scale biological systems is problematic and the interpretation of Fmiso PET images remains unclear.
This complexity renders problematic the interpretation of biomarker results, and it differs between practitioners or centers.
In general, the interpretation of mortality versus admissions is problematic because deaths are coded to the underlying cause whereas admissions are coded to the cause of admission.
Specifically, 74 is problematic for my account because the interpretation of the sentence is not consistent with the expected meaning from the structure in 75a.
This approach has the advantage that it is independent of changes in treatment or in underlying cancer incidence, both of which make the interpretation of changes in observed breast cancer mortality problematic.
This "Jumping PCR" generates apparent rare allele calls that could be problematic in interpretation of sequence data from outbred animals or human populations, but for sequencing studies using inbred mice, this type of low-frequency artifact is readily distinguishable from the expected homozygous allele calls.
Variability in cholesterol measurements frequently renders the interpretation of single or repeated cholesterol determinations problematic, complicating employee counseling within screening programs.
This formulation also sheds more light on the interpretation of SROCs, which is problematic in the case where only one pair of sensitivity and specificity is available.
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