Sentence examples for problematic in the absence of from inspiring English sources
And his alleged self-dealing at Retrophin is a perfect example of why this behavior is problematic: in the absence of rules preventing such practices, it would be far too easy for founders to loot the companies they run and leave other shareholders in the lurch.
However, the discriminative capacity of doublet codons is even more problematic in the absence of a sophisticated decoding apparatus (as it requires accuracy higher than of modern ribosome) and therefore, such a decoding system is unlikely to evolve in a pure RNA World.
However, definitive evidence of non-causality is problematic in the absence of placebo control.
Moreover, distinction between colonization and infection is problematic in the absence of invasive procedures or autopsy data.
In more general terms, conclusive evidence is problematic in the absence of solid familial segregation evidence, especially when established in vitro or in vivo biochemical readouts are unavailable.
Including the patient's perspectives when evaluating ankle fracture interventions may be problematic in the absence of a condition-specific patient-reported outcome measure empirically derived from lived patient experiences [ 49].
Furthermore, the TryR active site is large and relatively solvent exposed, which may make the discovery of low molecular weight, highly potent, competitive inhibitors problematic, especially in the absence of structural information from inhibitors bound into the active site.
This variability in their sensitivity to scoring patterns within the same dataset is problematic, and in the absence of an external reference standard, it is not possible to determine what degree of sensitivity is optimal.
However, the concept of economic system in Soqotra is problematic given the absence of a market mechanism to integrate the internal articulation between these three constitutive components.
But most problematic is the absence of Mary, who never gets a chapter to herself.
It has been proposed that immunosuppressive transforming growth factor β (TGF- β) release stimulated by binding of apoptotic cells to macrophages may be sufficient to avoid potentially problematic auto-antibody generation, even in the absence of clearance.
