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We chose not to use a combined endpoint for analysis, as although it may have increased the statistical power required to detect treatment effects, it can also be problematic in interpretation and generate misleading conclusions, particularly about the strength of reductions in mortality [20, 21].
This "Jumping PCR" generates apparent rare allele calls that could be problematic in interpretation of sequence data from outbred animals or human populations, but for sequencing studies using inbred mice, this type of low-frequency artifact is readily distinguishable from the expected homozygous allele calls.
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Blooming artefact from calcified atherosclerotic plaque or metal stents is also exaggerated at lower kV, which can be problematic in CTA interpretation [4].
Particularly, in cases where real-time observation over a long time period (>10 min) with single molecule sensitivity is necessary to detect enzymatic reactions with slow kinetics, photobleaching and blinking of fluorophores can be problematic in the interpretation of single molecule data.
Its phylogenetic position as reconstructed in our analyses renders problematic any interpretation in which Cheliomyrmex represents the ancestral army ant condition [ 14].
For this reason, we did not include MFCC, since they are particularly problematic in terms of redundancy and interpretation [6].
The application of these methodologies to the quantification of the very low levels of oestradiol in postmenopausal women is more problematic in terms of accuracy and interpretation.
The two technologies were highly complementary although the shorter read length in the pyrosequencing-derived ESTs is problematic in that they limit biological interpretations due to the reduced information content in the predicted protein sequence.
However, these assays and their interpretation can be problematic in some situations.
Nonetheless, baseline imbalances can result from insufficient randomisation and can be problematic for the interpretation, in particular for the primary outcome even if adjusted for.
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