Finally, the blinding concept of randomized controlled trials is particularly problematic in applications of physical medicine.
This is problematic in applications where the energy values are important, for example when placing small molecules in docking applications; the relatively small binding energy of the small molecule is drowned by the large energy due to atomic clashes that hampers finding the lowest energy state of the docked ligand.
Coumarins, as used in the biosensor that was outlined above (7), have limited photostability (9), and this may be problematic in applications where high-intensity light sources or long illumination periods are used.
(In application forms, where not filling in a field can be more problematic, you can offer "personal reasons" to explain why you left a job).
The significant dependence of derived stability constants on measured surface area and choice of site density is well known (e.g. [40, 43]), and may prove to be particularly problematic in the application of surface complexation models to natural sediments, where reactive surface area is difficult to assess [3].
This concept is, however, problematic in practical application because: value must be measurable (objective, interpersonally comparable and it should be possible to aggregate it as social benefits), value must reflect different perspectives and the conflict between individual and social value has to be solved.
However, the effect of quantisation noise present in the position feedback may become problematic in certain applications.
Such systems belong to a newly introduced category of chaotic systems with hidden attractors that are important and potentially problematic in engineering applications.
Sensitivity to the magnetic field in the direction transverse to the gradiometer axis is problematic in some applications and can be reduced by matching the mutual inductance between the secondary loop of the flux transformer and the magnetometer to establish a condition of shielding.
Duplicated reads are problematic in quantitative applications as they can be real or artificial [ 23, 24, 35, 36].
However, high magnetic field strength is problematic in human applications because of arising physiological effects such as nausea and visual abnormalities.
