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A gradual, stepwise acquisition model of codon reassignment can reconcile the opposed and problematic hypotheses of multiple gains versus a single gain with subsequent loss.
There are many problematic hypotheses and uncertainties about the meaning and the origins of the cognitive problems associated with schizophrenia, and these are still waiting for an answer despite the high and still growing trend of the scientific production in this area.
The biocentric perspective relies on a problematic teleological hypothesis.
We find the hypothesis problematic.
The restricted ventral flexion of the azhdarchid neck is problematic for this hypothesis [27], [29], as is the cross-sectional shape of the rostrum [27].
Other ecologists contend that the intermediate disturbance hypothesis is problematic.
However, a failing initial experience with CETP inhibitors has been most problematic for the HDL hypothesis [ 124- 126].
If this difference is not observed then it is problematic to accept the hypothesis of a genetic contribution.
The second hypothesis that problematic life-ending acts without explicit request will be found more often in the least educated [ 7- 9] was not confirmed by our results.
This is of course problematic if the null hypothesis is that the concordance rates are equal to a very low prevalence.
In general, starting out with the hope of using unstructured data to try to generate new hypotheses is problematic until the firms have "practiced" and gained expertise in using unstructured data to enhance their answers to an existing question.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com