The latter view, that memory becomes problematic when brain function is disrupted, has simple appeal, but is a nightmare from a therapeutic perspective.
Identification of a bid function is problematic.
For proteins with stringent structure/function relationships, evolving while maintaining function is problematic.
Assessing β-cell function is problematic because currently no clinical test has been agreed upon as being the gold standard in the way that the clamp has for the measurement of insulin sensitivity.
Triclosan's potential for hormone disruption (the science is strongest in support of its potential to disrupt thyroid function) is particularly problematic for Avon, which is arguably more visibly tied to pink-ribbon marketing and breast-cancer awareness than any other cosmetics company.
The concept of gene function is highly problematic for a number of reasons, not the least of which being that the way in which function is determined by the annotator is not generally made explicit in the annotation.
The measurement of executive function is especially problematic in younger children [ 15].
Assessment of thoracic spinal cord function is noted as particularly problematic (Steeves et al., 2007).
And a generous margin is indefinitely applied to gloss over day-to-day errors ('oh, just a few bugs!') — allowing problematic functioning to be normalized and sanctioned in all but a handful of outlier instances.
The selection of genes for phylogenetic analysis on the basis of their coding for conserved core functions is also problematic because these are also frequently the genes most likely to share the high homology that facilitates recombination and horizontal exchange.
