Sentence examples for problematic for the design of from inspiring English sources
The relatively large size of the SpdS active site [10 15 Å (1 Å=0.1 nm), Figure 2C] could again prove problematic for the design of inhibitors that conform to Lipinski's rule [ 52].
This requirement is particularly problematic for the design of high-voltage battery systems, for which an electrolyte candidate must be stable to both Mg metal (−2.37 V versus the normal hydrogen electrode, NHE) and the cathode-active material selected, which should ideally operate near +1 V (vs. NHE).
Aβ dimers are found in equilibrium between various topologies, and the absence of common structural features shared by the four species makes problematic the design of a unique inhibitor for blocking dimers.
On the other hand, networks like hypercube (where degree of a node grows with the size of a network) can provide the desired fault tolerance but the design of a node becomes problematic for large networks.
As a consequence, under asymmetric information, the design of these policies is problematic.
To understand problematic jets that plagued early implosion designs, other test methods were necessary, but the RaLa experiments played a primary role in the design of explosive lenses.
"I did not find many [problematic] things in there because the design of the app — the protocol — is quite straightforward," says Couprie when I contact him for comment.
This is often considered problematic for the mapping of patchily distributed intertidal macroalgal vegetation.
The perhaps most problematic part of the design is associated with the use of one scoring sheet for all observations.
This could be problematic for primer design for RT-qPCR analysis, since design of primers that amplify only one of the contigs encoding a specific protein, instead of all the copies of that gene, could give misleading expression data.
Antigenic variants of many pathogens are problematic for vaccine design and remain a major reason for the inability to control some infectious diseases.
