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Cannabis users are more likely to be at the problematic end of that spectrum.
In his speech today, Mr. DiIulio tried to draw some distinctions, saying, "At one end, the least problematic end from a church-state perspective, you have, say, faith-based organizations that do housing rehab work.
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The night before, Foote jolted awake at 1 30 a.m., having solved the problematic ending that had plagued him the last three months.
Despite its problematic ending, Don Carlos is regarded by some as Verdi's masterpiece, or at least his masterpiece prior to the Shakespeare operas of his last years.
Similar tools in the past have been heavily criticised by advocates of an "open" internet, saying such efforts can produce false positives - and that means content that is not particularly problematic ends up being taken down or blocked.
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However the interpretation of any echocardiographic changes seen alongside such abnormalities can be problematic (unless end-stage disease present) if normal cardiac dimensions and the reliability of these measurements are unknown.
He always found endings problematic, and the ending of Huck Finn has been considered a glaring weakness ever since the book was published.
Alignment quality is especially problematic in the end regions of the intraspecies alignments, because (1) the ends of local alignments are generally defined by falling scores, and (2) the paralogs used by CHAP are entire local alignments, though their corresponding orthologs are usually excerpts from longer alignments.
"Matthew Perry can't remember three years of Friends," blared headlines, after he admitted that his drug and drink addiction was so problematic towards the end of the decade that he had little or no recollection of seasons three to six.
However, he came to see another feature as problematic in the end: his implicit acceptance of a general comprehension principle (another sense in which his notion of set is unrestricted).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com