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Reconstruction of large bone defects remains problematic in orthopedic and craniofacial clinical practice.
Assessment of potential effects of exposure to disinfection by-products on the risk of specific birth defects is problematic because of rarity and diversity of the congenital malformations.
These strictures are particularly problematic in that the underlying esophageal defect, aperistalsis, and low or absent lower esophageal sphincter (LES) pressure all cause prolonged acid damage to the esophagus.
Nonetheless successful results have been achieved for small defect repair, the fixation remains really problematic for large defects, i.e. defects with areas exceeding 2 cm2.
It is often problematic to distinguish between a new or residual defect on lung scintigraphy or helical CT.
The spiraling of the LD around the circumferential defect enabled us to cover these problematic patients with ease and since the flap is "long" rather than "large" the donor closure can be easily affected.
Utley said the increase in the number and complexity of cases did not necessarily mean congenital heart defects were increasing or becoming more problematic.
In general, focused breeding could be used to develop low-defect varieties, and these could be deployed to problematic sites.
At such small sizes, defects at the molecular and even atomic scale become more problematic, so semiconductor equipment makers such as ASM and Applied Materials keep providing ever more precise and expensive tools.
To do so leaves you vulnerable to infection and can make you seem like the world's biggest hypochondriac – "Don't come near me with your cold!" "Do you have any antiseptic for this tiny scratch?" Methotrexate is particularly problematic for young women, as its use is associated with severe birth defects.
Although increasing numbers of childhood mental health problems are being attributed to genetic defects, reactive attachment disorder is by definition based on a problematic history of care and social relationships.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com