We submit that the proposed approach may bring about a new paradigm for improving behavioral technology and design of studies capable of identifying drugs with novel properties and rapid onset of improvement, while avoiding some problematic constructs in past biological research on depression.
With classical histology it is rather problematic to construct accurate 3D datasets, because of section alignment inaccuracies as well as unavoidable tissue distortions resulting from fixation, embedding, cutting and staining.
This construct is problematic.
Based on the problematic polygonal meshes, we construct a well-structured point-based model, Layered Depth-Normal Image (LDNI), in three orthogonal directions.
At the same time, we recognize that their use may construct a problematic dichotomy where everyone is seen as either male or female, reinforcing stereotypic ideas and neglecting that masculinity and femininity have multiple meanings both within and across cultures, regions, and countries.
Media sources have constructed problematic images about the Middle East, North Africa and South Asia (MENASA).
Nevertheless, paired format OPIs introduce a number of other problematic factors that relate to construct definition, reliability, and fairness.
Social support is a complex and multifaceted construct, understanding the problematic aspects in addition to the supportive aspects is important to effectively tailoring interventions that utilize social support to improve health.
But, these methods are often problematic when constructs with many gene cassettes are being built.
Mastery-avoidance goals represent a relatively new construct that may be conceptually problematic.
