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Infection continues to be a problematic complication of fracture treatment, particularly in severe open fractures.
Pancreatodigestive tract anastomotic site stenosis is a problematic complication after pancreatoduodenectomy.
Adjacent-segment disc degeneration (ASDD) is a problematic complication that can occur following lumbar spinal fusion [ 4, 5].
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Its usage is therefore complex and can cause problematic complications such as infection and thrombosis (Groeger et al, 1993; Verso and Agnelli, 2003).
In this regard, some GPs declare factors such as depression or anxiety to be among the most significant and problematic complications in treating patients with chronic pain [ 35].
However, we still believe that the relationship between MetS and knee OA deserves further study, because problematic complications such as deep vein thrombosis after procedures related to knee OA are known to be associated with MetS [ 9].
The questionnaire revealed several creative steps, based on laboratory considerations, being taken to prevent veneer chipping and fractures, a frequent and problematic prosthetic complication (Q12) (Figure 7).
However, despite improvements in file designs and metal alloys, fracture of rotary instruments during endodontic treatment still represents a problematic, unwanted and frustrating complication.
Regular blood transfusions are problematic, as they risk complications including developing antibodies, limiting further transfusion, having hemolysis (blood cells burst), iron overload, and infection.
Furthermore, therapy-related late effects, including short stature and neuro-endocrinological complications, remain problematic.
Early identification of diabetic foot ulcers (DFUs) destined for poor healing and/or infection-related complications remains problematic, often delaying and compromising treatment.
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