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Unfortunately, all three concepts of 'benefit', 'minimal risk' and 'minimal burden' are problematic both in terms of the underlying ethical issues as well as definition.
In particular, the exceedingly problematic genus Pseudemys, which has been a source of taxonomic uncertainty for over 150 years, while the box turtles (Terrapene) and map turtles (Graptemys) all remain problematic both in terms of species delimitation and within-genus interspecific phylogenetics [ 31- 35].
In particular, the failure to make human rights a prominent part of the talks has been problematic, both in terms of support for talks inside Iran, and for the long-term prospects of finding a sustainable, positive relationship with Iran.
The shortage of drugs to treat opportunistic infections was consistently mentioned by all health care professions as problematic, both in terms of treating patients and in terms of relations with the community.
Antibiotics are still the most potent weapon to treat bacterial infections, but the evolution of resistance is becoming increasingly problematic both in hospitals (Kutateladze and Adamia 2010) and in agriculture (Johnston 2002).
Confirming the presence of CHD in primary care in the UK can be problematic, both in accessing cardiac investigations (such as exercise ECG or angiography) and interpreting the results [ 31].
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Delays could prove problematic for the GBT both in terms of attracting the remaining private donations and keeping construction costs under control.
However, such a distinction was problematic, both theoretically and in practice, particularly given that medical research regulation was law-based while regulation of other research was voluntary.
As a wavering Christian and occasional rationalist, I've always found Easter (which I sometimes think of as the New Testament's Passover 2.0) a singularly problematic holiday, both in its cheery, secularized aspects and its grisly, credulity-straining religious form.
Staphylococcus aureus strains resistant to multiple antibiotics are increasingly common causes of serious and problematic infections both in hospitals and communities [12], [13].
In court filings, the university claimed that Dr. Davis's performance "was problematic in both her dealings with students and in her capacity as an administrator".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com