Sentence examples for problematic and frustrating from inspiring English sources

To date, the most reliable prognostic indicator for colorectal cancer (CRC) has been stage, but discerning which of those patients with stage II or III disease will be among the 25-51% of cases to develop recurrent cancer and succumb to the disease remains one of the most problematic and frustrating issues concerning clinical care and cancer surveillance strategies for CRC patients.

"And frustrating.

Bizarre and frustrating.

"It is disheartening and frustrating".

It is slow and painstaking and frustrating.

Fascinating and frustrating in equal measure.

It just gets too exhausting and frustrating.

An opaque and frustrating film.

It's disgusting and frustrating.

Albahari's narrative is gnarled and frustrating.

It's weird and frustrating.