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The preclinical models for predicting cardiotoxicity, including induced pluripotent stem cells and zebrafish, are reviewed, with the hope of eventually being able to identify problematic agents before their use in patients.
Instituting rigorous due diligence reviews in this way serves both to identify problematic agents and to provide a legal defense in case of a stray violation.
This dichotomy indicates that antimicrobial resistance is a major selective advantage that drives the ongoing rapid clonal expansion of these highly problematic agents of nosocomial infections.
Parasites from Perkinsus sp. family are considered to be one of the most problematic agents being blamed for mass infections leading to dramatic reductions in culture beds of clams Ruditapes descussatus in Southern Portugal [ 3, 4].
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It is one of those classic "problem" essays that dominate the current age of criticism; in this case, the problematic agent wasn't necessarily Bee herself but the fact that, as Douthat writes, American entertainers had been "pushed to shed their genteel limousine liberalism and embrace the race-gender-sexual identity agenda in full".
But Klosterman, who weighs Goetz's story against the tidy cinematic vigilantism of "Batman" and "Death Wish," said via e-mail that he resists the Zimmerman comparison: "With Goetz, you're looking at a person reacting to crime and, at least from the perspective of someone living in New York in 1984, operating as a problematic agent against the violent conditions of the city.
The area has been problematic for agents, Castrejon said, both in terms of crossings and assaults on Border Patrol agents.
What about that painful late-season demise of the Red Sox, Mr. Epstein's recent problematic free-agent signings or the burdensome long-term player contracts he inherits?
Because the bureau would not employ these problematic techniques, our agents who knew the most about the terrorists could have no part in the investigation.
Failure of human actors to take appropriate action is equally, if not more, problematic than software agents failing.
Metformin monotherapy is a highly appropriate first-line pharmaceutical intervention as it reduces hyperglycemia without concomitant hypoglycemia or weight gain – side effects that are problematic with hypoglycemic agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com