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There is little research into horizontal wells with variable density perforation completion, and the ones that exist turned out to be very problematic: (1) The method for open-hole completion horizontal wells was used ignoring the fluid flow in perforation tunnels in these studies (Landman and Goldthorpe 1991; Yuan et al. 1996; Zhou et al. 2002).
However, there are two situations for which imputation has been problematic: (1) polymorphisms with low minor allele frequency (MAF), and (2) datasets where subjects are genotyped on different platforms.
However, inference drawn from health surveys is valid only under certain conditions, with bias arising from self-reports and nonresponse often being problematic (1).
A systematic review of published studies showed that physicians experience sickness certification as problematic, 1 and this was confirmed by later investigations, 2 8 even to such an extent that it was considered a work environmental problem.
The ECBI Intensity scale measures the frequency of disruptive behaviour along a 7-point scale (1 = never to 7 = always), and the ECBI Problem scale measures whether or not parents view those behaviours as problematic (1 = yes, 0 = no).
Fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) have been of recent interest, particularly for use in populations in which interpretation of glycated hemoglobin (A1C) may be problematic (1– 3), such as in the setting of anemia, hemolysis, or renal disease (4– 6).
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Studies from different countries on sickness certification have indicated that physicians, and especially GPs, experience the tasks and situations relating to sickness absence consultations as problematic [ 1, 3, 2, 5- 11].
For many people in the Baltics, the "post-Soviet" grouping remains problematic, 25 years on.
Julie Myerson tossed her problematic 17-year-old son out the door, blamed it on pot smoking and then cashed in by writing a book about it.
And you are unlikely to hear a better performance of the fascinating but problematic 75-minute Faust Symphony than that from Riccardo Muti and the Vienna Philharmonic.
Treatment of comminuted distal femur fractures is problematic [1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com