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To solve this problem, pathway-based analysis (PBA) has been introduced to GWAS data analysis.
Another factor is the involvement of medical doctors other than the regular source of care in scoliosis suspicion, as some patients may be followed by various physicians for other healthcare problems (pathway 4).
Prevalence of mental health problems, pathways through services, problems with research methodology and organisational factors in service provision are considered throughout to underpin the understanding of outcomes for young people in care.
For instance, although PathBLAST [ 20, 22] can implement query searches, it is mainly only applicable to small pathways – up to 5 proteins – mainly due to the dimensionality problem with pathway length, and has limited support for identifying non-exact pathway matches.
Given an instance of a Find-Branching-Pathways problem, find a pathway P satisfying the constraints of Find-Branching-Pathways such that | P| ≤ | P'| for any other pathway P' satisfying the constraints.
However, in order to rank all viable biosynthetic pathways ρ(c) for a compound c of interest, the problem of pathway enumeration needs to be addressed.
The work presented here differs from most of these studies in that (i) our network approach is totally unsupervised and (ii) that we tackle the specific problem of pathway module activity estimation without reference to a particular phenotype.
Some progress has been made in tackling the gene-environment interaction problem using pathway analysis to demonstrate the role of genetic variants in exposure-related cancer susceptibility (c.f. Malhotra et al. (498)), but very little research has been done on in-utero exposures to mixtures of chemicals that act on cancer-related mechanisms.
IIM conceptualized the problem, plausible pathways for resolution and drafted the manuscript.
The PRA integrates all aspects of the problem (causes, pathways, and receptors) without resorting to extensive modeling.
Research on CAN has lagged behind in many areas, none more so than in understanding how individuals suffering from the broad range of cannabis-related problems resolve those problems, and how their characteristics and problem resolution pathways are similar to or different from alcohol [ALC] or other drugs [OTH].
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