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One further general limitation of this review can be seen in the problem of transferability of the results.
Due to the universal structure of the CPN, the problem of transferability in TREAT concerns only the medical domain factors, not the topology of the system.
The problem of transferability is addressed in the context of CPNs, emphasising the advantages of use of CPNs for solving the problem.
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Furthermore, we discuss problems of transferability of such a system from one site to another as well as problems of local susceptibility patterns and individual dose regimens.
Despite general problems of transferability of preclinical results to clinical settings, our study suggests that small animal PET imaging using a suitable animal model combined with ex vivo and in vitro experiments is a practicable approach for comparative Aβ tracer assessment.
Accordantly to model the problem of assessing transferability of health cost evaluation across locations we identified 60 final factors of variability (e.g. unit cost of chest radiograph).
An alternative solution to the problem of the limited transferability (e.g. robustness) of a model may be to identify the environmental factors that affect the model's prediction accuracy and incorporate them into it.
To solve this problem, the transferability of wheat and barley microsatellite markers (or Simple Sequence Repeats; SSR) to wild related species was evaluated [ 22, 23].
The problem addressed in this contribution is that of transferability – making projections into situations that are statistically independent from the training data, and such measures of model performance have been shown to be overly optimistic [38].
The 2454 AFLP loci mapped in the TAMU-ARS population by [ 25] were excluded from this study due to the problems in transferability of this marker type among laboratories, as discussed by [ 52].
It has been questioned if randomized controlled trials conducted under optimal conditions are able to address questions of effectiveness and efficiency of clinical interventions in health care systems adequately [ 27], because of the problems of applicability and transferability from controlled trial conditions to real-life conditions in communities.
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