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It may be seen as a problem of the presented study that the patients are not blinded and a bias in the provided answers cannot be fully excluded.
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Further general problems of the presented studies are their heterogeneity and lack of comparability with respect to the number of patients included, inclusion criteria (type of tumor, tumor stage), different treatment concepts (palliative treatment versus curative treatment including radical surgery) and different genotypes.
While the requirement to alleviate acute somatic ailments before discharge in these studies might have prolonged relatively short stays, other factors in the context of somatic ailments might have shortened relatively long stays in the presented study, such as problems of the patient to participate in therapeutic measures.
One problem of the present study relates to the number of excluded patients which was over half the patients.
At first glance, the problem of the present study may appear to be most similar to (2).
As a further step in the investigation of this problem, in the present study, we used comparative transcriptomic analysis to establish the set of genes belonging to the RosR regulon.
Based on the objective of the problem, in the present study, single-point crossover is considered.
The instrument is interview-administered, and the patient is asked to name three to five important activities that they are unable to do or have difficulty doing as a result of their problem (in the present study: their hand OA).
The patient responds in free text to the following question: "Today, are there any activities that you are unable to do or have difficulty with because of your problem?" In the present study we modified the PSFS question as follows "Which activities do you consider it important to improve?" As in the PSFS, the patients were asked to identify one to three activities.
Based on the data of Spine Day 2012 (an annual action day where Swiss school children were examined by chiropractors on a voluntary basis for back problems), the aim of the present study was to gain systematic epidemiologic data on adolescent spinal pain in Switzerland and to explore risk factors per gender and per spinal area.
To address this problem, in the present study, the SIF of a crack in a ship detail was calculated by combining a PATRAN finite element model for the whole ship with the advantages of ANSYS for SIF calculation, incorporating a macrocode written to achieve the transformation.
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