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The last problem of the method is that it finds an eigenvalue density description instead of a set of eigenvalues.
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However, the fundamental problem of the methods is that definition of what constitutes an active scaffold is highly subjective[6].
Author's response: The description of the problem, of the methods and of the examples has been revised as suggested.
The main problem of this method, the distribution of knots, is extensively investigated.
However, as mentioned in [7], the problem of this method is that the stability of the estimated AR model is not guaranteed.
Combined with the known mass loss problems of the method, this leads to the observed deviations [33].
Although the MSEPF-MMSF method has good performance, the primary problem of this method is determining the optimal values for the parameters N m, σ r, and Q.
However, the problem of this method is that it does not preserve the periodicity of data.
The problem of this method is a computational cost that increases in proportion to the size of an environment.
A known problem of the watershed method is over-segmentation.
The possible problem of the SAXS method lies in analyzing the obtained data.
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