Sentence examples for problem of substantial from inspiring English sources

But it seems unlikely that this approach will resolve the core problem of substantial pricing uncertainty.

Background: The quality of medication use in older adults is a recurring problem of substantial concern.

The problem of substantial molecular evolutionary rate heterogeneity does not appear to be present in the Ovalentaria AHE dataset.

In order to avoid the problem of substantial variability in published estimates of body mass and length, we pooled studied taxa into appropriate weight/length categories (Table 1).

The bacteria cause severe infections after surgical treatments and infect implanted material, thereby posing a problem of substantial clinical relevance (20, 26, 27 ).

We also identified a problem of substantial positive bias in harm rate estimates where there are high levels of inter-patient variation.

Numerical results demonstrate that the method converges and show its capability to handle a number of flow problems of substantial current interest.

The complexity, granularity and dimensionality of the problem require of substantial computational resources that are not affordable by regular CPU-based architectures.

Indeed, given the recent increase in the extent of C. difficile death and illness in North America and Europe, the findings in this study show that CDAD is an emerging problem, worthy of substantial investment in effective infection-control and monitoring systems.

This work consequently deals with the problem of achieving substantial load sharing in bonded/bolted joints.

Mr Shields told BBC Radio Ulster he found the level of failures in registration "surprising" and added that prior to the report, there had been no anecdotal evidence to suggest that there was "a problem of any substantial size", He pointed to the assembly and council elections in May 2011, when about 668,000 people turned out to vote in Northern Ireland.