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The phrase "problem of subsistence" is correct and usable in written English.
You would use it to refer to a difficulty or challenge related to providing the necessary sustenance or livelihood for a person or group of people. For example, "In many parts of the world, the problem of subsistence plagues rural communities."
Exact(1)
In a 1930 essay on "Economic Possibilities for our Grandchildren", John Maynard Keynes mused on a future 100 years thence, when much of humanity would have solved the perpetual economic problem of subsistence.
Similar(59)
Hominin ingenuity can been seen in the broadly similar patterns of technological development across much of the globe, with comparable solutions independently developed to solve what were likely common problems of subsistence or survival.
Whether Panathinaikos' fan-funded model can bridge that gap is open to question, particularly in a country where people have problems of daily subsistence far more important than funding football.
Colonisation of the Pacific islands may share similar frameworks and problems as periods of subsistence transition in other parts of the world.
The main weakness in the proposal to use disguised unemployment for the construction of major social-overhead-capital projects arises from an inadequate consideration of the problem of providing the necessary subsistence fund to maintain the workers during what may be a considerably long waiting period before these projects yield consumable output.
But when it is proposed to move a large number of surplus workers away from their home villages for major construction projects taking a considerable time to complete, the problem of raising a sufficient subsistence fund to maintain the labour becomes formidable.
A theme to which Mohist texts return repeatedly is the problem of meeting the basic subsistence needs of the common people.
For example, in Kosovo, auditors discovered that "software problems" apparently accounted for overpayments of subsistence allowances to the tune of $324,000.
"I placed myself in the situation of subsistence farmers in Africa, those populations affected by the problem, and looked at the resources these people have at hand to develop a tool that would empower them to address this life-threatening problem more independently from expensive imported know-how and technologies," he says.
However, many human populations worldwide, particularly those who have traditionally based their mode of subsistence on pastoralism, can continue to drink milk into adulthood without problems, because lactase expression persists in the gut.
Just a matter of subsistence?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com