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In pharmacokinetics, the first methods of inference were applied almost thirty years ago to the clinical problem of dose regimen [ 9].
In the clinical setting, we have always faced the problem of dose limitation, defined as the systemic toxicity of conventional chemotherapeutics, an issue that can potentiate the MDR tumor phenotype.
14 IMRT resolves the problem of dose uncertainty and the target volume issue at lymphatic in the neck, as it enables the primary tumor and the upper neck nodes to be treated in 1 volume throughout, thus providing excellent locoregional control of NPC. 15 However, there is still a problem with how to approach failures associated with the first treatment for the neck lesion.
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In this paper, the problem of dose-volume constrained optimization in IMRT planning is defined to obtain the unknown variable (x in{mathcal{A}}) if the system is acceptable.
In the second phase, the aim was to evaluate the effectiveness of the community pharmacist intervention in addressing the problem of dosing inadequacy when compared with usual care.
The study shows the effectiveness of a community pharmacist intervention in addressing the problem of dosing adequacy of drug treatment in polymedicated elderly patients over 65 years with renal impairment.
27 28 The problem of effective dose has never been addressed in clinical trials.
The problem of low dose or sub optimal use of acupuncture used in clinical trials has also been highlighted by several authors.
To address the problem of missed doses, many newer drug formulations require less frequent dosing, often once daily.
Our findings show a slightly different perspective to the noncompliance problem of renal-dosing guidelines and promote a CDS approach to reduce kidney-related drug-prescription errors.
Consider the problem of identifying a dose μ having pre-specified probability of failure using data from groups of subjects who arrive sequentially for treatment.
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