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The problem of cleavage wrinkles is also being tackled close to Los Angeles, the unofficial capital of breast implants.
The problem of cleavage prediction resorts to binary classification from computational point of view.
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The original vector was also modified to pTY-shRNA-EF1a-GFP-IRES-puroR to circumvent the problem of incomplete cleavage by the 2A protease.
To overcome the problem of rapid proteolytic cleavage of radiolabelled 11, we substituted the l-amino acid spacer (FFK) by its d-amino acids counterpart ffk (12) resulting in high metabolic stability in vivo.
When siRNAs are administered via lipofection to mammalian cells, one potential problem is cleavage of siRNAs by endogenous cellular endonucleases.
Additionally, we account for the problem of arising neo-epitopes and cleavage sites by formulating the problem of designing a spacer sequence as a multi-objective optimization problem that maximizes the recovery probability of the desired epitopes, minimizes the immunogenicity of neo-epitopes, and (optionally) minimizes the cleavage probability at non-junction sites at the same time.
When they see even a small amount of cleavage, "it creates a big problem".
Jessica must have been feeling particularly confident in her gym clothes and shades that day, because she had no problem showing off a very, er, generous amount of cleavage.
We would like to thank Yuguang Mu and Kai Tang for introducing us the problem of SNP discovery using base-specific cleavage and mass spectrometry.
We also addressed the problem of neo-epitopes and non-junction cleavage sites arising from spacer sequences and the order of the epitopes within the string-of-beads by extending the formulation with two additional objective functions.
Although the use of cleavage site-specific proteases (e.g. Thrombin) has overcome the problem of non-specific cleavage they still could render the stalk-less NA head prone to dissociation into non-active NA monomers or dimers.
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