In addition, metronomic chemotherapy regimens minimize or even eliminate the problem of chemotherapy-induced host responses that may actually secondarily promote tumor growth and malignancy after causing an initial and beneficial anti-tumor response.
Targeted drug delivery strategies have shown great potential in solving some problems of chemotherapy, such as non-selectivity and severe side effects, thus enhancing the anti-tumor efficiency of chemotherapeutic agents.
Against this background, this paper addresses the problem of combination chemotherapy with dose adjustment.
However, for patients with AIDS-related lymphoma, the problem of intrinsic chemotherapy resistance persists (Little et al, 2000).
Furthermore, the MTX/LDH nanohybrids were reported to overcome drug resistance in cancer cells which is a major problem of clinical chemotherapy [ 30], as well enhancing their cellular recognition through surface modification with cancer cell targeting ligand, folic acid [ 24].
Previously considered a primarily surgical management problem, the contribution of chemotherapy, radiotherapy and the combination of chemo-radiation, to the management of colorectal cancer has now been demonstrated.
One of the main problems of present chemotherapy is the development of resistance of tumor cells towards drug-induced apoptosis.
Poor compliance and compromised blood supply are the two major problems of adjuvant chemotherapy.
In order to provide a clear understanding of the proposed methods, systematic and effective design tools of SDRE control are illustrated on a single-inverted pendulum nonlinear benchmark problem and a practical application problem of optimally administering chemotherapy in cancer treatment.
If effective, cancer vaccines directed against Brachyury could circumvent the problem of resistance to chemotherapy and radiation and help decrease the rate of metastasis of human carcinomas characterized by overexpression of Brachyury.
