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The Nobel Prize in Physiology or Medicine was awarded Monday to three American scientists who solved a problem of cell biology with deep relevance to cancer and aging.
"The problem of cell death is pretty common in stem-cell treatment," said Prof Murray, "When we try to regenerate with liquid tissues, like blood or bone marrow, we're pretty good at it, but we haven't been very successful with solid tissues.
Inherent in these cultures is the problem of cell death, which can result from nutrient depletion, byproduct accumulation, and other bioreactor stresses which signal the cell to die through apoptosis, or programmed cell death.
The demand for biotherapeutics for the treatment of many of today's diseases is outpacing the manufacturing capabilities of mammalian cell culture due to the inherent problem of cell death.
We consider the joint optimization problem of cell sectorization, transmit power control and multiuser detection for a CDMA cell.
The common problem of cell spreading between pillars also caused the force-deflection relationship of calibrated pillar to be no longer well defined.
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Cancer is usually presented as a problem of cells becoming mindless replicators, proliferating without purpose or restraint.
"We do know that both epigenetic and genetic changes contribute to the problem of cells not doing what they're supposed to do," adds Feinberg, who has studied epigenetics for decades.
We approach this problem of cell-scale post-translational regulation in the context of presenting a method for the decomposition of the range of functional capabilities of large biochemical reaction systems.
For another, Losick adds that bacteria are a rich system for studying problems of cell biology.
However, the major problems of cell survival, cell fate determination and engraftment after transplantation, still remain.
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