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"problem in itself" is correct and usable in written English.
You can use it to refer to a single difficulty or complex situation that presents a problem. For example: "The fact that the deadline had been missed was a problem in itself, and made it even more difficult to finish the project on schedule."
Exact(60)
Which presents a problem in itself.
Escape has become a problem in itself.
And that is a problem in itself.
And yet that became a problem in itself.
However… I developed social phobia, which is a bad problem in itself.
And Eshkol's reluctance to respond was soon seen in Israel as a problem in itself.
That spread, all the way to the continent's westernmost part, is not a problem in itself.
The fact that they have claimed the room as their own is a problem in itself.
Still, some forecasters say the pessimistic talk may be overblown, and possibly a problem in itself.
This is not a problem in itself – the obstacle lies in the way those markets operate.
This is quite natural and is not a problem in itself.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com