These, in total 40 probe split into two sub-sets of 10 probe pairs for each allele which we will term 'allele-set'.
Probe splitting was seen in one case, indicating that LPL rearrangements do occur in vivo, albeit rarely.
Consecutive pair-wised hybridisations using distal and proximal probes relative to the estimated breakpoints were selected until a probe with split signal was observed.
In order to model target binding along all positions of a probe, we split the target into all possible sequences that are ≥2 base pairs (bp).
The SNO and SS functionalities of modified proteins can be reduced to free thiol (SH) by selective chemical reactions, and therefore using two isotopologues to probe one split sample in parallel can lead to simultaneous quantitation of protein thiols in the SNO, SS, and SH chemical states.
Genes have different probe annotations using different databases, either because genes in a subset of databases have more probes in the probe set, or the original probe set is split into separate probe sets to represent alternative splicing transcripts.
Combination of BRET probes and split-RNA probes enables to choose and detect target RNA sequences.
Including half the probes in a split set, about 7.8% of probes will produce a different gene expression finding than the majority of probes designed for each gene.
Unlike the other binary probes consisting of split primary sequences, this binary probe consisted of two folded modules and was referred to as a folded binary probe (Endo & Nakamura 2010).
Actually 74.2% (46/62 cases) of cases with positive signals of the PML/RARA rearrangement by the PML/RARA probe, showed absolutely negative results with the RARA split probe.
