AFM force spectroscopy now allows probing of mechanical properties of soft biological samples [20], [21], [22], [23], [24] and measurement of inter- and intramolecular interactions between biomolecules, thus providing new insights into the molecular bases of macromolecular elasticity [25], [26], protein folding [27], and receptor-ligand interactions [28].
This method of data acquisition allows for real time optimization of optomechanical transduction in our devices, which facilitates sensitive probing of their mechanical motion, allowing for precise measurements of physical quantities, such as forces [18] and torques [21].
Pores with undulating opening diameter have the potential of extending the resistive-pulse technique beyond sizing and provide a high-throughput technique of probing mechanical properties of meso and micro-objects.
While presenting a very direct way of probing mechanical properties of cells, the above-mentioned micropipette and SFM-based techniques are inherently slow due to comparably long preparation or measurement times for each cell.
We probe the influence of mechanical strain, such as would be applied through a substrate, on the distribution of space charge.
Based on the tests data, the physical process of dynamic ice forces in crushing failure was probed, by analysis of mechanical behaviour of ice under compressive loading related to relative loading speed of ice-structure interaction.
Although some fundamental investigations have been carried out to probe the effect of mechanical stimulation on articular chondrocyte physiology [ 1, 5– 11], the relevant studies are, to some extent, not comprehensive.
Together, our findings provide a new and straightforward approach capable of probing local mechanical properties of highly compliant viscoelastic materials with millimeter scale spatial resolution, mitigating complications involving contact detection or sample geometric constraints.
This review is aimed at providing a sound foundation for linking observed AE with various micro-mechanical failure events in geologic granular materials, not only for monitoring of triggering events preceding mass mobilization, but also as a non-invasive tool in its own right for probing the rich spectrum of mechanical processes at scales ranging from a single grain to a hillslope.
Measurements in the plane plane geometry have been attempted in the framework of Casimir force studies, in order to probe the theoretical predictions of mechanical effects related to quantum vacuum fluctuations [2, 3, 13].
Single units with meningeal receptive fields were detected by their firing of action-potentials in response to mechanical probing of the parietal dura mater.
