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Diffusion-weighted MRI (DWI) characterizes tissue by probing changes in random water molecule mobility related to differences in the tissue microstructure.
These techniques provide information on aerosol volatility by probing changes in size/volume of aerosol particle population, in gas-phase composition via mass spectrometry using thermal desorption or Knudsen cell based methods.
Destabilization upon Na+ or K+ interacting with carboxylate AgNPs was evaluated probing changes in multiple physicochemical characteristics: surface plasmon resonance/optical absorbance, electrical conductivity, pH, hydrodynamic diameter, electrophoretic mobility, surface charge, amount of Na+/K+ directly associated with AgNPs, and Ag+ dissociation kinetics.
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Robert Langer, a professor of chemical and biomedical engineering at the Massachusetts Institute of Technology, is using multiphoton microscopy to probe changes in tissue as part of his work developing new methods, including ultrasound, to deliver pain medications and insulin directly through the skin.
They are beginning to probe changes in the brain with fMRI.
X-ray photoelectron spectroscopy was used to probe changes in carbon surface chemistry.
In situ ellipsometric measurements have been used to probe changes in the polymer films induced by the applied potential.
[1-13C] pyruvate pre-polarized via DNP has been used in animal models to probe changes in metabolic enzyme activiaies in vivo.
Reflectance spectroscopy can probe changes in epithelial nuclei that are important in pre-cancer detection, such as mean nuclear diameter, nuclear size distribution and nuclear refractive index.
Fluorescence spectroscopy can probe changes in epithelial cell metabolism, by assessing mitochondrial fluorophores, and epithelial-stromal interactions, by assessing the decrease in collagen crosslink fluorescence that occurs with pre-cancer.
Oxidative footprinting coupled with mass spectrometry (MS) is used to probe changes in the solvent accessibility of amino acid side-chains concurrent with the folding process, by quantifying the degree of oxidation experienced by the wild-type protein relative to a kinetically trapped, three-helical folding intermediate and an unfolded variant that lacks secondary structure.
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