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The GFP-based Ca2+ indicators comprise the camgaroo and pericam probes based on a circularly permutated GFP, and the cameleon probes, which rely on the fluorescence resonance energy transfer (FRET) between two GFP mutants of different colors.
However, this goal has been achieved only partially, as most of the methods, especially the immunological and molecular ones, usually rely on the use of probes based on a narrow range of features, such as epitopes or DNA sequences.
Novel biotin-tagged photoaffinity probes based on a trifunctional tertiary amine scaffold were synthesized and evaluated as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors.
We have developed a conceptually new design strategy for fluorescent probes based on a combinational use of photo-induced electron transfer (PET) and excited-state intramolecular proton transfer (ESIPT) mechanisms.
Two Zn2+ ion fluorescent probes based on a coumarin Schiff-base were designed and synthesized, which have highly selective sensing of Zn2+ ions over other metal ions in aqueous solution based on a CN isomerization mechanism.
A novel set of PCR primers and oligonucleotide probes based on a 16S ribosomal RNA gene was designed for RLB detection of both Anaplasma species, and the performance of the molecular assays compared.
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Boero, G. et al. Electron-spin resonance probe based on a 100 mu m planar microcoil.
Here we introduce a chemical probe, based on a water-soluble phosphine warhead, which reacts with the crotonyl modification.
A new portable, pocket-size NMR probe based on a novel permanent magnet arrangement is presented.
A novel fluorescent probe based on a boron dipyrromethene (Bodipy) derivative for Au3+ has been designed, synthesized, and characterized.
Therefore, the metrological characteristics of a miniature optical micro-probe based on a Michelson interferometer are evaluated.
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