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Activity-based probes, based on detecting specific enzymatic activity in a cellular context, are powerful tools for enzyme activity assays (Heal et al. 2011).
Both cuvette- and cell-based studies revealed that thiol probes based on nitrobenzofurazan scaffolds are deactivated by H2S.
We developed a new web-based program SLICSel for the design of hybridization probes, based on nearest-neighbor thermodynamic modeling.
We designed DNA probes based on previously described HCR initiator sequences17.
We have developed chiroptical probes based on biphenyl chromophores.
Clinical arthroscopic probes based on indentation testing are being developed.
We get an NIH New Innovator Award for the project "Engineering Bioimaging Probes Based on Triggered Molecular Geometry".
Two novel fluorescence probes based on conjugated Schiff base for the detection of Zn2+ were developed.
These results provide fundamental knowledge required to design miniaturized electroanalytical probes based on gallium electrodes.
Two novel Schiff-base fluorescence probes based on triazole and benzotriazole were designed and synthesized.
Probes based on Pt0.8Ir0.2 were fabricated and employed in all the investigations.
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