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DOI: http://dx.doi.org/10.7554/eLife.06074.012 We probed the significance of the interactions seen in the crystal structures by studying how various mutations affect the rate of autophosphorylation and enzymatic activity.
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This study is aimed at probing the significance of some controlling parameters on CBM performance by a statistical approach.
A series of 11-residue peptides (ATRA-1, -2, -1A and -1P) were designed to probe the significance of the conserved residues within the ATRA motif, and their contributions to antimicrobial performance.
Secondly two probabilistic finite element simulation studies were conducted, examining heel pad stress and femoral strain fields, respectively, to demonstrate how SPM can be used to probe the significance of field-wide simulation results in the presence of uncontrollable or induced modeling uncertainty.
The WorldPost deployed its global newsroom to probe the significance of the results in several nations, producing this report with an eye toward highlighting what is working and what needs to be most urgently addressed.
Large scale functional screening provides an ideal strategy to probe the significance of NATs [43].
A two-pronged approach was taken to probe the significance of βα-hairpin clamps in TIM barrel proteins.
To probe the significance of Spt5 regulation of this gene, we asked whether and where in the fogsk8 embryos the de-repression of gadd45b results in overall mRNA increase, through whole-mount in situ hybridization.
We use this model to probe the significance of Homer (associated with the postsynaptic density) physically linking mGluR to IP3R1.
This will provide starting points for many labs working on phylogenetically diverse systems to probe the significance of these findings.
Endogenous alanine residues within this region were substituted to leucine residues to probe the significance of the size and/or geometry of their methyl side chains.
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