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After probe-independent hydrolysis of the alkylated substrate, the mixture of oligonucleotide products is mass mapped by ESI FTMS analysis, which enables the unambiguous identification of probed bases from the unique mass signatures provided by the different chemical modifiers.
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Herein we designed a peptide-based probe based on the proximity-induced protein conjugation reaction.
A new Hg2+-selective reaction-based probe based on thiophosphinated N,N-diethylrhodol was developed.
Activity-based probes, based on detecting specific enzymatic activity in a cellular context, are powerful tools for enzyme activity assays (Heal et al. 2011).
Rather, ALKBH2 appears to detect damaged bases by probing their base-pair stability.
Both cuvette- and cell-based studies revealed that thiol probes based on nitrobenzofurazan scaffolds are deactivated by H2S.
We developed a new web-based program SLICSel for the design of hybridization probes, based on nearest-neighbor thermodynamic modeling.
Molecular Probes, based in Eugene, Ore., had sales of $56 million last year from fluorescent markers used to label molecules in biology research.
We designed an oligonucleotide probe based on the DNA sequence.
We have developed chiroptical probes based on biphenyl chromophores.
Clinical arthroscopic probes based on indentation testing are being developed.
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