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In later purification runs, before pooling αSyn-containing SEC fractions for AEC, we routinely probed a range of SEC fractions with specific antibodies that recognize the principal contaminating proteins and one that detects αSyn.
With the exception of a series of 21 short Likert scale questions asked at the end of the interview, which probed a range of factors that were thought to potentially assist with contextualizing participants' discussions of the SPCH approach by differentiating levels of importance, the questions posed were open-ended.
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In particular, this experiment allows us to probe a range of dynamical regimes and independently tune the biochemistry (crosslinking) to study the coupling of tensile strain to network density and fiber orientation in a controlled setting and investigate the origin and generality of these mechanical processes.
The sampling technique was designed to probe a range of perspectives.
The strength of PET imaging is the range of radiolabelled tracers that are now available clinically to probe a range of tissue properties.
While this criterion is proposed as a minimal objective, an optimal therapeutic will provide the flexibility to probe a range of Aβ-lowering activity, including nearly complete lowering, in order to understand the relationship between Aβ lowering and efficacy.
We then probe a range of potential mechanisms for this rapid effect (Fig. 1): first, we rule out PI3Ks as mediators of the effect of VPA (as we had previously suggested) (Xu et al., 2007), because cells lacking all type I PI3K activity in a single cell line still show VPA-sensitive phosphoinositide levels.
From the nanotomography data, the pore diameters probed span a range of approximately 30 to 1.5×10 nm, which is in fairly good agreement with the range probed by mercury porosimetry, although the PSD shapes present some differences.
Namely, the use of detergent to probe the structural stability of PrPSc revealed that classical BSE was more resistant to detergent treatment (as probed over a range of detergent types) than was German L-type BSE [ 41].
Several types of excited states are accessible for these systems, which can be probed on a range of timescales by these techniques.
In subsequent years, the theoretical efforts at MIT gradually expanded and, over time, probed a wide range of topics from cosmology to exoplanets.
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