Probe splitting was seen in one case, indicating that LPL rearrangements do occur in vivo, albeit rarely.
Consecutive pair-wised hybridisations using distal and proximal probes relative to the estimated breakpoints were selected until a probe with split signal was observed.
In order to model target binding along all positions of a probe, we split the target into all possible sequences that are ≥2 base pairs (bp).
The SNO and SS functionalities of modified proteins can be reduced to free thiol (SH) by selective chemical reactions, and therefore using two isotopologues to probe one split sample in parallel can lead to simultaneous quantitation of protein thiols in the SNO, SS, and SH chemical states.
Combination of BRET probes and split-RNA probes enables to choose and detect target RNA sequences.
Unlike the other binary probes consisting of split primary sequences, this binary probe consisted of two folded modules and was referred to as a folded binary probe (Endo & Nakamura 2010).
Including half the probes in a split set, about 7.8% of probes will produce a different gene expression finding than the majority of probes designed for each gene.
This paper presents a new Electromagnetism-like Mechanism (EM) algorithm with Split, Probe and Compare feature (SPC-EM).
The split probe strategy allowed detection of down to 10 viral nucleic acid equivalents of CoV from all known CoV groups.
The proposed algorithm replaces the local search segment of a standard EM with a new search scheme named Split, Probe, and Compare (SPC).
