Sentence examples for probe criteria from inspiring English sources

Selective inhibitors of HMTs, many of which do not meet the chemical probe criteria, have been reviewed previously.

It is worth to note that many selective HMT inhibitors reported to date do not meet the chemical probe criteria we outlined in this review.

Of these three compound classes, only compounds represented by scaffold C fulfilled the final probe criteria of activity (<1 μM) and selective inhibition of NOD1-induced NF-κB activation.

In this review, we adopt the chemical probe criteria defined by Frye, Workman and Collins, and Bunnage et al. Therefore, high quality chemical probes are defined here as small-molecule inhibitors that have (1) high in vitro potency with an excellent and well-characterized selectivity profile, (2) a clear mechanism of action (MOA), and (3) robust on-target activities in cells.

For example, using a stringent 3 consecutive probe criteria, deletions of ~100 bp require microarrays with probes staggered ≤ 45 bp while smaller deletions of ~30 bp need probes staggered ≤ 32 bp and deletions of a just a few bp require probes staggered ≤ 12 bp.

For a fixed log ratio threshold, if a proportion and number of adjacent probes are chosen such that both methods have the same TPR, the FPR level is frequently higher when using the adjacent probes criteria (Table 1 and Additional file 2).

The number of probes for each contig depended on the ability to create suitable probes according to NimbleGen probe selection criteria and was limited by the small size of some transcripts and the minimum spacing criterion of 15 bp apart.

However, as we discover in this work, continual changes in genomic sequence annotations and probe design criteria make it difficult to compare gene expression data even from different generations of the same microarray platform.

The current state of the art of the field is examined, and principled thermodynamic probe design criteria are proposed that are based on the free energy of the probe target complex at the hybridization temperature rather than its melting temperature.

Detection of pathogens or gene families represented in a genomic DNA sample requires different probe design criteria than those used for gene expression, ChIP-chip or resequencing purposes.

Roche NimbleGen's CGH probe design criteria was utilized.