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First principle quantum chemical methods and atomistic simulations are used to probe active sites, ensembles, and reaction environments and assist in their design for metal catalyzed reactions.
The probe active area is 1.5 mm for striatal regions and 2.75 3.25 mm for the mPFC.
The Berkowitz group has a longstanding interest in the synthesis of unnatural phosphonates and in their use to probe active sites and glycoprotein receptor binding pockets, for example.
Western blotting confirmed that wt c-Src was activated in HCT116 when induced thus these data together confirmed that clone 28 can reliably probe active c-Src by IHC. Figure 1A v) shows positive staining with clone 28 staining of the MDA MB231 breast cancer cell xenograft consistent with the reported high levels of this breast cell line (Ito et al, 2002).
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Progression of pollen grains from freshly dehisced anthers to pollen tubes 4 h after germination is accompanied with > 5,161 (14.9%) gametophyte-specific expressed probes active in at least one of the developmental stages.
To further characterize cathepsin probe-active cells, total Mono-Nuclear Cells (MNCs) were prepared from intestine of 5-month-old APCΔ468 mice.
This study integrates deliberate material fabrication with density functional theory (DFT) calculations to probe intrinsic active sites, e.g. the defects and oxygen functionalities on graphene for activating OO bond in peroxymonosulfate (PMS) toward catalytic oxidation.
The present experiments demonstrate both forms of AK distinguished by ANS probe are active.
To guide inhibitor design, we used diversely substituted 3-aryl and 3-heteroaryl benzoic acids to probe the active site of OXA-48 for useful enzyme-inhibitor interactions.
The catalytic cyclotrimerization of alkynes on reduced TiO2(0 0 1) surfaces has been explored to probe the active sites for carboncarbon bond formation.
The transition state analogue 2,3-didehydro-2-deoxy-N-acetylneuraminic acid (DANA), which inhibits sialidases but is a poor inhibitor of trans-sialidase, was used to probe the active site conformation of mutant enzymes.
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