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This value is calculated by taking the probability of the least probable valid alignment corrupted with two extra base mismatches.
The submissions did not involve either known or probable valid biomarkers.
Matches to other gene signatures could only suggest potential toxicities, as these are not probable valid biomarkers.
We suggest that the most probable valid link will be the one with the higher score (or having rank one among the sorted list of computed scores).
According to the FDA guidance for pharmaceutical companies on pharmacogenomic data, biomarkers must be categorized into three classes: (1) exploratory biomarkers, (2) probable valid biomarkers, and (3) known valid biomarkers [ 20].
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If the affidavit alleged, and the warrant found, "probable cause," then his initial detention was probably valid.
Results of the receiver operating characteristics (ROC) analysis indicated that the RMI score with a cut-off 136 or less performed only slightly better than chance in delineating probable malingerers from valid responders in this setting.
In a previous study by our group, the ICD-9 code of 710.3 was validated against detailed medical record review and was found to be adequately valid for a probable diagnosis of dermatomyositis according to Bohan and Peter criteria with a positive predictive value of 70% [ 11].
It also states that valid warrants require "probable cause" and a particular description of the place to be searched and the persons or objects to be seized.
The common assumption was that the dialectic syllogism is an indubitably valid deductive scheme, but that probable premises produce only probable conclusions or opinions (Buridan, Quaestiones, 19; Buridan, Summulae, 347).
MODALITY in propositions is termed as modalization, and is about how probable or frequent the information is valid.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com