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These results predicted TMK (S. aureus) and NMT (C. albicans) as the most probable targets for the antibacterial and antifungal activity of these newly synthesized agents.
In March 1990 the Supreme Court of Ireland in Dublin blocked the extradition of James Pius Clarke and Dermot Finucane on the grounds they "would be probable targets for ill-treatment by prison staff" if they were returned to prison in Northern Ireland.
Future studies should examine the underlying interrelated pathophysiology in order to identify probable targets for treatment to reduce cardiovascular and renal complications.
Similarities in the growth characteristics and gene expression patterns of normal NSCs and brain tumor CSCs suggest that pathways important for NSCs are probable targets for eliminating brain tumor CSCs.
Similarities in the growth characteristics and gene expression patterns of normal NSCs and GSCs suggest that pathways important for NSCs are probable targets for oncogenic brain tumor stem cells.
AMPK, a phylogenetically conserved serine/threonine protein kinase and a metabolic sensor expressed in almost all mammalian cell types, is considered to be a novel common determinant in neurodegenerative diseases and one of the probable targets for major anti-AD drugs [ 31– 31].
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These combined results suggest that EVI1 is a probable target for the 3q26 amplification in HCC.
- CNTNAP2 is a prime candidate gene for the theory of mind phenotype in the human faculty of language and, therefore, a probable target for epigenetic evolutionary changes.
Long intergenic tandem repeats are well known targets for structural variation, and in this study we investigate whether exonic STRs share this property, and hence may serve as a probable target for exonic disease causing mutations.
Although all three cell sources have the capacity to be genuine CSCs, in our view, adult stem cells appear to be the most probable target for malignant transformation, generating cells with stem-like properties and tumorigenic potential [ 6, 9, 10] and accounting for cancer as a 'stem cell disease' [ 9].
Due to the higher apparent rate of turnover of the M1G bases, and the structural similarity of etheno adducts, we hypothesized that etheno DNA base adducts would be likely to undergo oxidation, with the imidazole ring being a probable target for oxidation.
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