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Dr. Evans said that sirtuin research was promising but unproved, and that he did not agree that sirtuin was the probable mediator of the famine reflex, a concern that "calls into question the second pillar of the GSK investment".
This model uncovered HIF-1α as a probable mediator of the therapeutic effects in this disease [ 16- 18].
AMPK has been proposed as a further probable mediator of the effects of LKB1 on cell polarity (Zhang et al., 2006).
The logic that lower income may limit the purchase of more costly, healthier foods is supported by evidence that diet cost is a probable mediator in the relationship between SEP and diet quality.
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Neurotrophic factors are probable mediators of these pathophysiological events.
Some of them are involved in the control of cellular gene expression and phenotype, and are probable mediators of the tumorigenic action of Snail1.
The probable mediators of aggrecan degradation are aggrecanases.
They are the most probable mediators of regulated liver uptake of I-FGF19 in this study.
Infant undernutrition and illness episodes were considered to be probable mediators of any effect of postnatal CMD on child development.
Probable mediators of new bone formation such as BMP2 are induced in different cell types (including synovial fibroblasts and cartilage cells) by proinflammatory cytokines such as TNF and interleukin-1 [ 46, 47].
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