As a result of its effects on multiple signaling pathways, including nonkinase targets, and its probable ATP-competitive binding mode, the use of piceatannol (and likely analogs) as a biological probe likely offers no advantages over other more potent and moderately selective ATP-competitive probes.
The probable reason is the exceedingly competitive nature of research in many fields.
In the longer term, in a competitive environment, it is probable that only the fresh milk segment of the industry is sustainable.
Probable mechanisms for the CMT-CTX interaction include competitive microsomal enzyme inhibition and/or acutely depressed hepatic blood flow.
(k) of this section, which is the Competitive, Special, and Facilities Research Grant Act, to reflect the probable intent of Congress.
It is quite probable that future elections to the EP will be even more competitive than the one in 2014.
In pricing products of perishable distinctiveness, a company must study the cycle of competitive degeneration in order to determine its major causes, its probable speed, and the chances of slowing it down.
The Steelers would argue that Testaverde should have been listed as probable on an injury report, and by not doing so, the Jets received a competitive advantage.
Other competitive traits, such as stem elongation and apical dominance, are the most probable candidates to exhibit plastic responses contingent on kinship of neighbours.
Although we were unable to obtain X-ray crystal structures for our best compounds bound to the protein, direct and competitive ITC experiments strongly implicate the FxxA binding region as the most probable binding site.
