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Up to 20 age-matched and sex-matched potential controls were selected for each case, a number of controls considered reasonable for achieving adequate statistical power, given the probable attrition.
The current TB drug development pipeline also has extensive activity in the early stages (Zumla et al, 2013), but there is a gap, corresponding to late preclinical development and phase I clinical trials, that needs filling to ensure continuity of clinical activity and to compensate for the probable attrition among the more advanced candidates.
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More probable is a long war of attrition with the Rwandan army suppressing the rebels but never defeating them, as long as they can hide in the mountains and forests of Eastern Congo.
Since efficacy in one or more preclinical animal tumor models generally provides the rationale in support of a new anti-neoplastic drug's probable benefit in humans, is the primary modifiable cause of attrition of new drugs a consequence of poor prediction of human activity/potency from animal models?
In conclusion, it is not probable that sample bias has led to drastically distorted results, in particular because attrition has resulted in an "upwardly biased" sample where it is likely that associations with socioeconomic indicators could have been attenuated.
In 1699 the British mathematician John Craig used probability to vindicate the truth of scripture and, more idiosyncratically, to forecast the end of time, when, due to the gradual attrition of truth through successive testimonies, the Christian religion would become no longer probable.
Maybe attrition.
A probable?
The attrition continued.
Possible, but not probable.
But it seems probable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com