The median probability of protection for high-protection PAs is 18% while the median for lower categorized PAs is 15%.
The seroprotection rate represents the percentage of recipients with an antibody titer at which the probability of protection is assumed to be 50%, but protective levels are poorly standardized and may vary among studies and between vaccines, and indeed between individuals.
But it is not as accurate as Markov method in assessing the hidden failure probability of protection.
The model assumes that there is a monotonically increasing relationship between immune response and probability of protection, that there will be a range of responses occurring in the vaccinated population and that the responses to different immunogens in a vaccine will vary from being negatively to tightly positively correlated.
Clinical studies were inconclusive, showing either a low probability of protection (16.7% among septic patients) or even a possible relation to mortality and infections.
Through in silico analysis with predicted amino acid sequence alignment, StreptInCor candidate vaccine had high sequence identity with 46 of the 48 emm-types described here (identity ranged from 94.5 % to 59.7%%, mean of 71%%), which is an important property for the probability of protection.
In such cases, data from animal studies are used to develop models relating antibody level to protection probability in the animal, and then data from a study or studies in human subjects vaccinated with the proposed vaccine regimen are used in combination with the relevant animal models to predict protection in humans, and hence estimate vaccine efficacy.
One which is often used is to work out hidden failure probability of relay protection devices and how it changes with the electric parameters (voltage, current, and line power flow) by taking the equipment's software/hardware and control scheme into account.
Possible selective advantages of insemination include increase of the probability of fertilization, protection of the gametes from a potentially harmful environment, the temporal and spatial separation of mating and oviposition, and sperm competition [ 23].
Intake of dietary fibers has been reported to be associated (i) inversely with the probability of having protection against insulin resistance in non-diabetic patients [ 37] and (ii) with enhanced insulin sensitivity in type 2 diabetes, whatever the type of fiber [ 38].
