We also assessed the potential effects of veterinary drugs on embryo damage and immunodepression increasing the probability of acquisition and proliferation of pathogens causing fatal disease [6], [10] [12], [21].
Specifically, model results indicated that the probability of CSC symmetric proliferation is responsible of a switching-like behavior which discriminates between tumorigenesis and unsustainable tumor growth.
Applying our methodology to this model we found that the probability of CSC symmetric proliferation is responsible for a switching-like behavior.
The plots at the bottom of Fig. 1 show an example of probability density of a proliferation indicator in tumor (red line) and normal cells (green line), respectively.
In order to perform survival analysis and create probability curves dependent upon tumour rates of proliferation and apoptosis as well as systemic cytokine levels the Kaplan Meier method was used.
Another way of representing observed differences in cell number between tip and stalk cells, would be to change the rate of proliferation, and keep the probability uniform.
The resulting proliferation could increase the probability of mistakes being made in DNA replication and setting these mistakes as mutations.
Cell behaviour at each stage of maturation is described by parameters of death rate, proliferation rate and a probability of differentiation.
