Suggestions(2)
Exact(6)
Here the probability of objective O1 is defined by, for example, P (O 1 ) = 0 existing three steady states 1 otherwise.
Moreover, pooling all published studies evaluating this putative association further suggests that KRAS mutations strongly negatively affect the probability of objective response to cetuximab treatment.
Increasing tumor tissue c-MYC mRNA levels were not significantly associated with an increasing probability of objective response (p = 0.62; hazard ratio 1.04; 95% CI 0.90-1.20).
Using a linear logistical regression model, the probability of objective response linearly increases with average paclitaxel exposure in mg/m/week with the slope significantly different from zero (Table 2 ).
This is consistent with a recent study that assessed the correlation of EGFR membrane staining with the probability of objective response or symptom improvement resulting from gefitinib treatment in IDEAL 1 and 2. The analysis found no consistent association between EGFR expression and clinical outcome (Bailey et al, 2003).
This result was later confirmed by a subsequent analysis of additional data, which reported that some of the immune-related adverse events were observed in 62% of 139 overall treated patients and were associated with a greater probability of objective antitumour response (P = 0.0004) [ 51].
Similar(54)
Open image in new window Fig. 5 Probability distributions of objective function with different correlation coefficients.
Table 8 Comparison of optimization results using different methods in ten-station system Methods Optimization results (MWh) Mean value Standard deviation Maximum Minimum LC 22745954.94 316343.84 23916060.70 21541920.97 LC-SB-SA 22751224.08 318074.77 23933036.68 21538074.23 Open image in new window Fig. 6 Comparison of probability distribution of objective Y.
Similar definitions are applied to the probabilities of objectives O2 and O3.
Baseline FDG-PET predicted the probability of an objective response, but not the probability of a metabolic response.
As Slovic [ 1] pointed out, little probability of the objective risk cannot stop the majority from assessing risk based on their own subjective judgments, which is called as the perceived risk.
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